Aug 27, 2009
These little gems deliver insulin for wound healing. Bacterial infection is a major health threat to patients with severe burns and other kinds of serious wounds such as traumatic bone fractures. Recent studies have identified another use for insulin as a weapon for fighting infection and healing wounds. These can also be used for chemotherapy and other local drug deliveries.
Using tiny nanodiamonds, researchers have demonstrated a method for delivering and releasing insulin to a specific location over a period of time. The nanodiamond-insulin clusters hold promise for wound-healing applications and could be integrated into gels, ointments, bandages or suture materials.
A wound site skin pH levels can reach very basic levels during the repair and healing process and researchers found that the insulin bound to nanodiamonds is released when it encounters basic pH levels.
A substantial amount of insulin can be loaded onto the nanodiamonds, which have a high surface area and can accelerate the healing process and decrease the incidence of infection. The results of the study were published in July by the journal Biomaterials.