Showing posts with label Aspirin. Show all posts
Showing posts with label Aspirin. Show all posts

Jun 10, 2016

Aspirin and Heart Attack

Your chest feels heavy, as if you are in a vise and the pain is spreading to your jaw and shoulder. What to do, call 911, then chew a single uncoated full-size 325-mg aspirin.

The reason you need aspirin is the same reason you should call 911. A heart attack is a dynamic event, and early intervention can limit damage. Paramedics can give you oxygen and medication, and they will monitor your blood pressure and heart rhythm to forestall complications. In the hospital, doctors take EKGs and blood tests to see if you are having a heart attack; if so, they will usually try to open the blocked artery with an angioplasty and stent or a clot-busting drug.

Most heart attacks develop when a cholesterol-laden plaque in a coronary artery ruptures. Relatively small plaques, which produce partial blockages, are the ones most likely to rupture. When they do, they attract platelets to their surface. Platelets are the tiny blood cells that trigger blood clotting. A clot builds up on the ruptured plaque. As the clot grows, it blocks the artery. If the blockage is complete, it deprives a portion of the heart muscle of oxygen. As a result, muscle cells die, a heart attack.

Aspirin helps by inhibiting platelets and just a tiny amount is needed to inhibit all the platelets in the bloodstream. Since the clot grows minute by minute, time is of the essence.
Studies show that a chewed aspirin needs only five minutes to reduce TxB2 concentrations by 50% and 14 minutes for the chewed tablet to produce maximal platelet inhibition, versus 26 minutes for an unchewed aspirin swallowed with water.

Aspirin can also help prevent heart attacks in patients with coronary artery disease and in healthy men over 50 years of age. Low doses, between 81 and 325 mg a day, are needed.

Mar 4, 2016

Aspirin Origin

On March 6, 1899 acetylsalicylic acid, was patented by The Friedrich Bayer & Co. under the trade name Aspirin at the Imperial patent office in Berlin. For over a century, it is still one of the most effective, versatile, and commonly used medications in the world.

Its active ingredient, salicin, had been used for many centuries to alleviate pain and fever. Hippocrates is known to have used it, and it had been used in modern medicine since the 19th century. As effective as it was, willow bark and salicin were used sparingly, because the taste was so bad, its use caused a severe upset stomach, and in extreme cases could even damage a stomach.

This changed when Bayer chemist Felix Hoffman created a form of the drug that was just as effective, but much better tasting and drastically easier on the stomach. Three years after Hoffman’s death in 1949, another scientist at Bayer, Arthur Eichengrün came forward claiming responsibility for Hoffman's work.

Eichengrün, who was imprisoned in the Theresienstadt concentration camp during World War II, maintained he was denied his due because he was Jewish.

Either Hoffman or Eichengrün also perfected another medication around the same time as Aspirin. Heroin was was believed to have even greater potential. It was created to be a non-addictive alternative to morphine for such ailments as labor pains and curing heavy coughs.

When Aspirin was first recommended to Heinrich Dreser, head of the pharmacological laboratory at Bayer, he rejected it, supposedly stating “The product has no value.” Once Heroin quickly began to fall as people realized how addictive it was, he revisited his decision regarding Aspirin and it quickly became Bayer’s best selling product. After World War I, Bayer had to give up its  trademark on Aspirin as part of the Treaty of Versailles in 1919.

Aspirin sales slumped with the introduction of other over-the-counter pain relievers such as ibuprofen and acetaminophen, but sales rebounded when clinical trials showed that a small daily dose of Aspirin could lower the risk of heart attack and stroke. Today, approximately 40 billion Aspirin tablets are consumed annually.

Feb 19, 2016

Ten German Inventions

MP3 - A German inventor, Karlheinz Brandenburg is responsible for an invention that has revolutionized how we listen to music.

Ring binder, ink eraser, hole punch, glue stick - Confirming the stereotype that Germans like to keep orderly records of everything, some of the most useful office supplies have been invented by Germans. Friedrich Soennecken invented ring binders and hole punches in the late 19th Century. Another German, Louis Leitz, then improved on the invention by putting a finger hole in the binder to make it easier to remove from a crowded shelf.

Aspirin - The world's favorite painkiller made from willow bark was developed by Felix Hoffmann in August 1897 for pharmaceutical giant Bayer, and although a US company claimed the patent for the drug after the First World War, 12,000 of the 50,000 tons of aspirin produced each year are still made by Bayer.

Carabiner - The most important piece of gear in any climber’s equipment was invented by Otto Herzog, a Bavarian climber and inventor. The carabiner has many uses, but this metal loop with a spring-loaded gate is most commonly used to allow a climber to safely scale or descend a steep cliff with the aid of a rope.

Lithography - Invented by Alois Senefelder in Bavaria in 1796, lithography has given the world some of its finest art. Most famously, Edvard (sic) Munch used the printing technique, but Picasso, Monet, Manet and more have also used the technique.

Accordion - When asked to think of Germany, one often thinks of a portly man wearing lederhosen, and a green hat, playing folk tunes on a huge accordion. In fact, early versions of the instrument date back to third century BC China. But the first 'true' accordion was invented by a German, Christian Friedrich Buschmann, who in 1822 attached bellows to a portable keyboard with vibrating reeds, naming it a 'hand-aeoline'.

X-ray machine - The first X-ray machine was invented by Wilhelm Conrad Röntgen, physics chair at the University of Würzburg. He apparently discovered the unknown radiation, which he marked with an x, while investigating cathode rays. He noticed that the radiation could pass through human tissue, but not bones.

Contact lens - Although Leonardo da Vinci is said to have been the first man to come up with the idea of a contact lens, it was a German by the name of Adolf Gaston Eugen Fick who first made a contact lens and successfully fitted it to the human eye. Fick’s prototype is could only be worn for an hour or two at a time due to its unwieldy size.

Playmobil - Playmobil was invented by Hans Beck in the 1970s with the idea to make a flexible toy that was still simple enough for young children to understand. With the original toys being an American Indian, a cowboy, and a builder, the little figures were a hit as soon as they came on the market.

Airbag - Walter Linderer came up with the idea of using compressed air in a bag which would inflate when the bumpers of two cars made contact. He patented it in 1951, although his design did not inflate fast enough and had little practical value at the time.

May 29, 2015

Tylenol vs. Advil vs. Aleve

Here is a handy chart which shows the best uses for these common pain killers. I think Aspirin is a bit under reported in the chart.

May 30, 2014

German Inventions

Although it has now been replaced by the Celsius temperature scale in almost all countries except for USA and Belize, Fahrenheit (in which water's freezing point is 32 degrees and boiling point is 212) was the world standard until relatively recently. It was invented by German physicist Daniel Gabriel Fahrenheit in 1724.

Aspirin, made from willow bark was developed by Felix Hoffmann in August 1897 for pharmaceutical giant Bayer, and although a US company claimed a patent for the drug after World War One, 12,000 of the 50,000 tons of Acetylsalicylic acid (Aspirin) produced each year are still made by Bayer.

After using blotting paper from her children’s school books to remove unwanted coffee grounds, Dresden housewife Melitta Bentz had the idea to patent her invention in 1908. She then founded a company selling over a thousand coffee filters by the next year.

German clock manufacturer Junghans Uhren Gmbh developed a watch that automatically adjusts itself to an atomic clock using radio signals. It was invented in 1990 and will remain accurate to the second for at least a million years.

The first true working car was invented by Germans Karl Benz and Gottlieb Daimler in 1886, 22 years before the Model T Ford went into production in the USA.

The first true accordion was invented by a German, Christian Friedrich Buschmann. In 1822 he attached bellows to a portable keyboard with vibrating reeds and called it a "hand-aeoline".

In 1977 after nine years of development, German inventors Jürgen Dethloff and Helmut Göttrup created the first card with a built in programmable microprocessor, the ancestor of the chip and PIN cards in our wallets today.

Sep 24, 2011

Aspirin the Wonder Drug

Most of us know to take an aspirin immediately at onset of a heart attack and that it is good to cure headaches, hangovers, and relieves modest aches and pains, but this old wonder drug is good for many more things.

One crushed aspirin in a gallon of water helps keep plants alive during transplanting, or cutting. Stressed plants can't absorb nitrates and phosphates but the aspirin solution is easily absorbed. It also works to prolong cut flower arrangements.

Salicylic acid is in many acne treatments, and is an ingredient in aspirin. Crush an aspirin or two and mix with water to make a paste to put on a pimple. In a few minutes and rinse without rubbing. The size and redness should diminish soon.

Nov 12, 2009

My mother said, "Take your Asprin."

She must have known something. Aspirin may be good for your liver, protecting it against damage from too much Tylenol and possibly even from obesity and alcohol abuse, according to a new study by a Yale physician, Dr. Wajahat Mehal of Yale, published in the Journal of Clinical Investigation. It shows liver damage can be prevented by low doses of aspirin and has a protective effect, preventing inflammation of the liver caused by many medications.