Cancer Stages and Grades

Cancer is the name given to a collection of related diseases. In all types of cancer, some of the body’s cells begin to divide without stopping and spread into surrounding tissues.
Too many of us are aware of the prevalence of cancer in our society. Two words often come up, but are not universally understood. Staging is for the cancer itself and grade references the actual tumor. There are different grading systems for different types of cancer. For instance, there is Gleason for prostate cancer, Bloom-Richardson for breast cancer, Fuhrman for kidney cancer, etc.

Cancer stage refers to the size and/or reach of the original (primary) tumor and whether or not cancer cells have spread (metastasized) elsewhere in the body. Stages do not change from initial diagnosis, even if the cancer becomes more aggressive. This is important for consistent statistical analysis.

Stage 0 (zero) Abnormal cells are present, but have not spread to nearby tissue. Stages I, II, and III indicate cancer is present. The higher the number, the larger the cancer tumor and the more it has spread into nearby tissues. Stage IV shows the cancer has spread to distant parts of the body.
Staging is usually based on the TNM system of classifying cancer. In the TNM system, each cancer is assigned a letter or number to describe the tumor, node, and metastases. T stands for the original (primary) tumor. N stands for nodes and tells whether the cancer has spread to the nearby lymph nodes. M stands for metastasis.
Tumor grade is the description of a tumor based on how abnormal the tumor cells and tumor tissue looks under a microscope. There are four grades G1 Well differentiated (low grade), G2 Moderately differentiated (intermediate grade), G3 Poorly differentiated (high grade), and G4 Undifferentiated (high grade). Grade 3 and 4 tumors tend to grow rapidly and spread faster than tumors with a lower grade.

Low-grade cancer cells look more like normal cells and tend to grow and spread more slowly than high-grade cancer cells. Cancer grade may be used to help plan treatment and determine prognosis.
In addition, there are two tumor types, benign, such as moles and warts and malignant, where the cells invade the surrounding tissue and organs.

Generally, there are five cancer stages, four tumor grades, and two tumor types, benign and malignant. Unlike school, a high stage or grade is not good.

Chemotherapy and Hair Loss

Chemotherapy, sometimes referred to as chemo is the use of medicines or drugs to treat cancer. There are more than 100 chemo drugs. Chemo may be used to: Keep the cancer from spreading, slow the cancer’s growth, kill cancer cells that may have spread to other parts of the body, relieve symptoms such as pain or blockages caused by cancer and, in some cases, cure cancer. Different types of chemotherapy work in different ways and have different side effects. It can be administered as a pill, liquid, shot, IV, or rubbed on the skin.

Most cells in the human body divide using a process called mitosis. When a cell reaches the end of its lifespan, it gets destroyed in a pre-programmed process called apoptosis.

There are over 200 many types of cancer. All types are a result of unregulated cell growth. Cells that divide more rapidly than apoptosis can regulate is simply too much mitosis. The result is excessive tissue, known as tumors. Tumors can be localized or spread through the lymphatic system or blood stream.

Many chemotherapy drugs are administered in combinations and work by interrupting mitosis and most cannot differentiate between abnormal cancer cells and normal healthy cells. Because of this, any cells that multiply rapidly can also be affected by chemotherapy.

Fast growing cells are found in hair follicles, lining of the mouth, stomach, and bone marrow. Since these fast growing sites are also affected by chemo, the result can be hair loss, decrease in production of white blood cells, and inflammation of the digestive tract, etc. Luckily, healthy cells, like hair follicles and the others usually repair themselves, so hair loss temporary. Radiation can cause some of the same symptoms, but that story is for another day.