Get a head start as spring is beginning to blossom (except for those in the Northeast). Mix one ounce of vodka or vinegar , a few drops of dish soap, and two cups of water in a spray bottle. This works best on weeds that grow in direct sunlight. The vodka breaks down the waxy coating that protects the leaves, and helps the weeds dehydrate. Ants also do not like to cross a path of the mixture.